疾控中心的建设要符合我国现行的生物安全实验室各项标准,目前国际上依据实验室所处理对象的生物危险程度,把生物安全实验室分为四级:一级对生物安全隔离的要求最低,四级最高。我国目前有两个四级生物安全实验室:湖北武汉BSL-4病毒实验室(中国科学院武汉国家生物安全实验室 )和国家动物疫病防控高级别生物安全实验室(中国农业科学院哈尔滨兽医研究所)。
Digitising process development can reduce the time delay between sampling and availability, and can increase the quality of the data obtained
Process control is a central task in bioprocess development and production. Apart from common control tasks including pH, temperature or dissolved oxygen, more advanced control tasks must be mastered. Real-time availability of analytical data is ofte
To facilitate optimal process control limiting substrates must be identified, moni-tored and controlled. Amino acids are often critical substances, especially in mam-malian processes. Measurement and thus monitoring is tedious and rarely done.
HPLC is the common reference method for product and metabolite analysis in bio-processes. Sampling is needed for these analyses, resulting in off-line measure-ments along the process. In order to reduce time and cost expenses in process development a