比较五种在线检测方式用于谷氨酸棒状杆菌在分批补料培养下的生长监测

2022-03-31

实验使用用谷氨酸棒状杆菌WT菌株ATCC13032。实验装置（如图 1）有 Lucullus（Securecell，瑞士）和EVE生物工艺平台设备（瑞士，Infors）作为工艺监控和记录的信息管理系统。

Automated bioreactor sampling for on-line analysis of amino acids using two approaches: HPLC and Cedex® Bio HT Analyzer

2020-03-10

To facilitate optimal process control limiting substrates must be identified, moni-tored and controlled. Amino acids are often critical substances, especially in mam-malian processes. Measurement and thus monitoring is tedious and rarely done.

On-line HPLC analysis and data integration with Numera and Lucullus PIMS shown on the example of a CHO process

2020-03-10

HPLC is the common reference method for product and metabolite analysis in bio-processes. Sampling is needed for these analyses, resulting in off-line measure-ments along the process. In order to reduce time and cost expenses in process development a